#19681
Re: Novavax (NVAX): Un Nuevo Comienzo
Sí, pero ha parado por eficacia. Y si dan un antiviral como este (hay varios estudios que van a dar resultados en los próximos meses) en cuanto das positivo, eso puede limitar mucho las hospitalizaciones. Lo que significa que los boost para gente no mayor o en riesgo ya no son tan necesarios; aún así, yo preferiría el boost de Novavax a jugármela con esto. Pero todo depende de los niveles de covid que haya el año que viene (y posteriores).
Eso sí, me parece muy poca gente en el estudio para los riesgos que tiene. No creo que la aprobación sea tan rápida. Algunos comentarios de red:
"700 plus in the study. A few comments. It appears to interfere with fidelity of transcription and thereby introduce multiple mutations, sufficient to be lethal/disabling mutations. Now if fully dosed and levels of drug are sustained, fine and dandy. If dosing is incomplete and just a few or certain key mutations are introduced I can imagine some troubling potential for creating escape variants for any drugs or vaccines. Just speculating of course but what could possibly go wrong with introducing enhanced mutation rates.
Last time I checked 48% was a lot less than 80%. Monoclonal antibodies reduced hospitalization by 80%.
So once again a mutagenic drug that is less effective than the drugs.available today. And of course vaccines reduced hospitalization by 95%
What could go wrong."
Nuestro amigo Rick Bright alertó de su desarrollo:
https://www.investorvillage.com/smbd.asp?mb=193&mn=144047&pt=msg&mid=22461123
"Raymond Schinazi, an Emory University chemist who has extensively studied the active ingredient in EIDD-2801 but has no connection to DRIVE, notes that his former pharmaceutical company, Pharmasset, abandoned it in 2003 after discovering its mutagenic properties. Schinazi says the small chemical tweaks made to increase the ingredient's bioavailability and transform it into EIDD-2801 are unlikely to change its mutagenicity. "Thank goodness someone is raising the red flag," about EIDD-2801,
Schinazi says. "You don't develop a drug that's mutagenic. Period."
But Bright notes in his complaint that "similar experimental drugs in this class had been shown to cause reproductive toxicity in animals, and offspring from treated animals had been born without teeth and without parts of their skulls."
Merck's new pill, Molnupiravir is EIDD-2801
Mutagenic definition
agent, such as a chemical, ultraviolet light, or a radioactive element, that can induce or increase the frequency of mutation in an organism.
Wiki: The mutagen produces mutations in the DNA, and deleterious mutation can result in aberrant, impaired or loss of function for a particular gene, and accumulation of mutations may lead to cancer. Mutagens may therefore be also carcinogenic.
Eso sí, me parece muy poca gente en el estudio para los riesgos que tiene. No creo que la aprobación sea tan rápida. Algunos comentarios de red:
"700 plus in the study. A few comments. It appears to interfere with fidelity of transcription and thereby introduce multiple mutations, sufficient to be lethal/disabling mutations. Now if fully dosed and levels of drug are sustained, fine and dandy. If dosing is incomplete and just a few or certain key mutations are introduced I can imagine some troubling potential for creating escape variants for any drugs or vaccines. Just speculating of course but what could possibly go wrong with introducing enhanced mutation rates.
Last time I checked 48% was a lot less than 80%. Monoclonal antibodies reduced hospitalization by 80%.
So once again a mutagenic drug that is less effective than the drugs.available today. And of course vaccines reduced hospitalization by 95%
What could go wrong."
Nuestro amigo Rick Bright alertó de su desarrollo:
https://www.investorvillage.com/smbd.asp?mb=193&mn=144047&pt=msg&mid=22461123
"Raymond Schinazi, an Emory University chemist who has extensively studied the active ingredient in EIDD-2801 but has no connection to DRIVE, notes that his former pharmaceutical company, Pharmasset, abandoned it in 2003 after discovering its mutagenic properties. Schinazi says the small chemical tweaks made to increase the ingredient's bioavailability and transform it into EIDD-2801 are unlikely to change its mutagenicity. "Thank goodness someone is raising the red flag," about EIDD-2801,
Schinazi says. "You don't develop a drug that's mutagenic. Period."
But Bright notes in his complaint that "similar experimental drugs in this class had been shown to cause reproductive toxicity in animals, and offspring from treated animals had been born without teeth and without parts of their skulls."
Merck's new pill, Molnupiravir is EIDD-2801
Mutagenic definition
agent, such as a chemical, ultraviolet light, or a radioactive element, that can induce or increase the frequency of mutation in an organism.
Wiki: The mutagen produces mutations in the DNA, and deleterious mutation can result in aberrant, impaired or loss of function for a particular gene, and accumulation of mutations may lead to cancer. Mutagens may therefore be also carcinogenic.
