ACTC
Sentimiento alcista y nueva patente (concedida tras 6 años, que ya es normal)
patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=%22advanced+cell+technology%22&OS=%22advanced+cell+technology%22&RS=%22advanced+cell+technology
Claim#1. A method of producing differentiated cells, comprising:
i) obtaining morula cells or inner cell mass cells from a human blastocyst by mechanical and/or enzymatic means
ii) inducing the morula cells or inner cell mass cells to differentiate directly into differentiated cells, wherein the inducing step comprises:
a) addition of a differentiating agent directly to the morula cells or inner cell mass cells or
b) placement of the morula cells or inner cell mass cells directly in a differentiation environment chosen from a flat adhesive environment, a microgravity environment and a 3D adhesive environment
iii) isolating the differentiated cells from ii), thereby producing differentiated cells.
It is a more specific object of the invention to provide a method for inducing genetically engineered inner cell mass cells to differentiate into progenitor cells which can be used for cell therapy or for the generation of tissues and organs for transplantation, wherein a desired gene is inserted, removed or modified in the genetically engineered inner cell mass cells.
It is another object of the invention to provide improved methods of transplantation therapy, comprising the usage of isogenic or syngenic cells, tissues or organs produced from the differentiated cells produced according to the invention. Such therapies include by way of example treatment of diseases and injuries including Parkinson's, Huntington's, Alzheimer's, ALS, spinal cord injuries, multiple sclerosis, muscular dystrophy, diabetes, liver diseases, heart disease, cartilage replacement, burns, vascular diseases, urinary tract diseases, as well as for the treatment of immune defects, bone marrow transplantation, cancer, among other diseases.
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