Farmas USA

Source: stocktwits

NEWS CELLCEUTIX!!!!!! (recien recibidas de la cia. por mail, aún no difundidas a la premsa)

Cellceutix Updates: Kevetrin™ Dosing Increases and Prurisol™ Anti-Psoriasis Drug Stability Tests Underway

Beverly, MA -- 06/17/13 -- Cellceutix Corporation (OTCBB: CTIX) (the "Company"), a clinical stage biopharmaceutical company focused on discovering small molecule drugs to treat unmet medical conditions, including drug-resistant cancers and autoimmune diseases, announces today that the pharmaceutical tablets for the Company’s clinical trial of Prurisol as a new drug candidate for the treatment of psoriasis have been formulated by Dr. Reddy’s Laboratories and are currently undergoing stability testing. The stability testing is scheduled to be completed in about 45 days.

“We have been advised that stability testing began approximately two weeks ago and that the Prurisol tablets will be shipped to the clinical site in Europe before the end of the 60-day stability research in preparation for the commencement of the clinical trial,” commented Leo Ehrlich, Chief Executive Officer at Cellceutix. “We are enthusiastic about reaching another milestone for our company with the start of second clinical trial. We are very optimistic about the potential for Prurisol to reproduce the laboratory results showing the drug to effectively eliminate all signs of psoriasis.”

Cellceutix also wishes to inform shareholders that it has recently conducted discussions with the University of Bologna regarding Kevetrin, the Company’s novel anti-cancer drug currently in clinical trials at Dana-Farber Cancer Center and Beth Israel Deaconess Medical Center, for the planned clinical trial as a new drug candidate for Acute Myelogenous Leukemia, or AML. All regulatory submissions have been made and the hospital is awaiting Kevetrin reaching its Maximum Tolerated Dose in the trials at Dana-Farber before commencing their trial.

“We are taking a different approach to realize some of the benefits of conducting the clinical trials of both Prurisol and Kevetrin in Europe,” said Dr. Krishna Menon, Chief Scientific Officer at Cellceutix. “It is a similar strategy that companies like Clovis Oncology employ to follow European protocol to target a broader, yet more specific, patient population. Through a promising pipeline and efficient development model, Clovis has built an impressive valuation. In our current trials at Dana-Farber, the protocol requires that we only treat Stage IV cancer patients, which presents its own set of unique challenges that can slow research. The good news is we are likely more than half way there in terms of the trial, and we are still increasing dosage. We are very pleased with the results to date especially considering the lower doses to date. With reference to the planned University of Bologna trial, by utilizing protocol where a ‘measurable stage’ of the disease is not required for the patient, i.e., we are not limiting the trial to Stage IV patients, this should allow the trial to go much faster, and hopefully get that perfect “poster”.

About Kevetrin™

As a completely new class of chemistry in medicine, Kevetrin™ has significant potential to be a major breakthrough in the treatment of solid tumors. Mechanism of action studies showed Kevetrin's unique ability to affect both wild and mutant types of p53 (often referred to as the "Guardian Angel Gene" or the "Guardian Angel of the Human Genome") and that Kevetrin strongly induced apoptosis (cell death), characterized by activation of Caspase 3 and cleavage of PARP. Activation of p53 also induced apoptosis by inducing the expression of p53 target gene PUMA. p53 is an important tumor suppressor that acts to restrict proliferation by inducing cell cycle checkpoints, apoptosis, or cellular senescence.

In more than 50 percent of all human carcinomas, p53 is limited in its anti-tumor activities by mutations in the protein itself. Currently, there are greater than 10 million people with tumors that contain inactivated p53, while a similar number have tumors in which the p53 pathway is partially abrogated by inactivation of other signaling components. This has left cancer researchers with the grand challenge of searching for therapies that could restore the protein's protective function, which Kevetrin appears to be doing the majority of the time.

Further information on the clinical trial, titled "A Phase 1, Open-Label, Dose-Escalation, Safety, Pharmacokinetic and Pharmacodynamic Study of Kevetrin (Thioureidobutyronitrile) Administered Intravenously, in Patients With Advanced Solid Tumors," is available at: http://clinicaltrials.gov/ct2/show/NCT01664000?term=cellceutix&rank=1

About Cellceutix

Headquartered in Beverly, Massachusetts, Cellceutix is a publicly traded company under the symbol "CTIX". It is an emerging bio-pharmaceutical company focused on the development of its pipeline of compounds targeting areas of unmet medical need. Our flagship compound, Kevetrin™, is an anti-cancer drug which has demonstrated the ability in pre-clinical studies to regulate the p53 pathway and attack cancers which have proven resistant to today's cancer therapies (drug-resistant cancers). Cellceutix also owns the rights to seven other drug compounds, including KM-133, which is in development for psoriasis, and KM-391 for the treatment of the core symptoms of autism. More information is available on the Cellceutix web site at www.cellceutix.com.

Safe Harbor Forward-Looking Statements

To the extent that statements in this press release are not strictly historical, including statements as to revenue projections, business strategy, outlook, objectives, future milestones, plans, intentions, goals, future financial conditions, future collaboration agreements, the success of the Company's development, events conditioned on stockholder or other approval, or otherwise as to future events, such statements are forward-looking, and are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements contained in this release are subject to certain risks and uncertainties that could cause actual results to differ materially from the statements made. Factors that may impact Cellceutix's success are more fully disclosed in Cellceutix's most recent public filings with the U.S. Securities and Exchange Commission.

Cellceutix Corp.
Leo Ehrlich
(978) 236-8717
[email protected]

Estaba echando un vistazo por ahi y me encuentro con que el dia de la debacle, el miercoles dia 12, justamente ese dia se actualiza el estado de la Fase 2 para cancer de pecho a TERMINADO y clinicaltrials.gov lo publica al dia siguiente:
"ClinicalTrials.gov processed this record on June 13, 2013"

Phase 2 Study of Thermodox as Adjuvant Therapy With Thermal Ablation (RFA) in Treatment of Metastatic Colorectal Cancer(mCRC) (ABLATE)
http://www.clinicaltrials.gov/ct2/show/NCT01464593?term=thermodox&rank=3

con todo el follon que hemos tenido alguien habia hablado de esto?
A mi me parece que no se ha dicho ni mu, ni en los foros usanos, ni en los articulos de seeking alpha, no?

y los resultados pueden liberarse en cualquier momento (quizas en la conferencia )

Que casualidad que justo el mismo dia liaran un BR del copon ... o no fue casualidad?

CLSN

Ahi os lo dejo para que lo penseis este finde ...

Estoy dentro con un +23%...mi objetivo son los 0,80$, pero no veo claros los rumores de los objetivos de la posible compra de Merck para el mercado europeo.A ver si el finde con mas tiempo puedo encontrar mas informacion.
DCTH.

Ya se que es muy tarde, pero felicidades Farmus por lo de tu Fase I en aumentar tu familia con un enano!
Y una vez ya finalizados los deberes de repasar en el Foro de las farmas, lo que ha pasado esta semana, activo el "modo apagado" y me voy pasar un dia de motos en Montmeló.
Buen fin de semana!

Ahora que mencionas stocktwits, fuente que consulto a menudo porque te da una buena visión de la masa retail, he visto este gráfico y casualidad o no me ha hecho pensar.

Relación ARNA - CLSN - AMRN

Y la foto del viernes del sector de las farmas, su performance y notoriedad en el retail.-

Ya veís que las que suenan son muchas de nuestras amigas aquí en Rankia.

joder, mi small cap preferida liderando el grafico ... que mal rollo ...

por cierto, tb miro stocktwits para tomarle la temperatura al retail.
Decia un tipo, " no os preocupeis con CLSN, con MNKD me hicieron lo mismo. Los "expertos" decian que estaba muerta y la tiraron , y se fue luego de 2 a 7. "
y efectivamente, gap down que recupero en apenas 2 mesesy de ahi para arriba sin parar ...