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The Stem Cell Revolution

y CRISPR

Enhanced Safety Profile: CRISPR-edited stem cell therapies should offer a safer class of therapeutics than any other technology. While CRISPR technology is often criticized for off-target effects, they occur less frequently in iPSCs than in other cells lines. Moreover, with stem cell therapy alone, patients have to undergo chemotherapy, suffering dangerous side effects. CRISPR-edited stem cell therapy eliminates the need for chemotherapy, while mitigating off-target effects.

Higher Efficiency and Lower Costs: iPSC cells spontaneously transform into more specialized cells, often making labwork quite difficult. With a shorter editing turnaround time, CRISPR lowers the probability that iPSCs differentiate into mature cells before the proper edits have been made, ensuring that the corrected genome is passed on to specialized cells. Typically, experiments require control tests, but replicating stem cell generated environments can be difficult. Alleviating that problem, CRISPR normalizes the genetic variability that exists across different iPSC cell lines. Additionally, CRISPRi, an application of CRISPR technology that silences genes instead of editing them, can reach efficiency levels of up to 95% in stem cells.

 

Editas Medicine (EDIT) signed a stem cell pact with GlaxoSmithKline (GSK) and Biogen (BIIB) for next-gen stem-cell therapies; CRISPR Therapeutics (CRSP) CRSP),+Casebia+Therapeutics+Sign+Commercial+License+Agreement+to+MaxCyte/12664463.html" rel="nofollow">licensed a CRISPR delivery mechanism for blood stem cells and has formed a CRISPR joint venture with Bayer (BAYZF); and Intellia Therapeutics (NTLA) has partnered with biotech giant Novartis NVS to focus on stem-cell based therapies.

https://seekingalpha.com/article/4084951-stem-cell-revolution

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